digoxin

Definitions:

  • A cardiac glycoside, C<sub>41</sub>H<sub>64</sub>O<sub>14</sub>, obtained from the leaves of a foxglove, <em>Digitalis lanata,</em> with pharmacological effects similar to digitalis.
  • a steroid glycoside, one of the cardiotonic chemical substances which is extracted from the foxglove. It is a white, crystalline substance (C41H64O14), and is a 3-substituted triglucoside of a steroid, related structurally to digitalin and digitoxin. It is used as a cardiotonic for treatment of certain heart conditions, such as congestive heart failure. Chemically it is (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide. The related compounds <xref urlencoded="digitalin">digitalin</xref> and <xref urlencoded="digoxin">digoxin</xref> are also extracted from the foxglove (<spn>Digitalis lanata</spn> and <spn>Digitalis purpurea</spn>). The class of steroid glycosides having cardiotonic properties are refered to as the cardiac glycosides.
  • A <xref>purified</xref> <xref>cardiac</xref> <xref>glycoside</xref> extracted from the <xref>foxglove</xref> plant, Digitalis lanata, widely used in the treatment of <xref>heart</xref> conditions such as <xref>atrial fibrillation</xref>.
  • digitalis preparation (trade name Lanoxin) used to treat congestive heart failure or cardiac arrhythmia; helps the heart beat more forcefully
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