- An acute, highly infectious, often fatal disease caused by a poxvirus and characterized by high fever and aches with subsequent widespread eruption of pimples that blister, produce pus, and form pockmarks. Smallpox was eradicated worldwide by 1979 as a result of numerous vaccination campaigns and exists only as a laboratory specimen.
- An acute, highly contagious disease, fatal in between one third and one fourth of unvaccinated cases.
- A contagious, constitutional, febrile disease characterized by a peculiar eruption; variola. The cutaneous eruption is at first a collection of papules which become vesicles (first flat, subsequently umbilicated) and then pustules, and finally thick crusts which slough after a certain time, often leaving a pit, or scar.
- An <xref>acute</xref>, highly <xref>infectious</xref> often <xref>fatal</xref> <xref>disease</xref> caused by a <xref>virus</xref> of the family <xref>Poxviridae</xref>. It was completely <xref>eradicated</xref> in the 1970s. Those who survived were left with <xref>pockmarks</xref>.
- a highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars